A STUDY OF β-HYDROXY-α-KETO ACIDS
نویسندگان
چکیده
منابع مشابه
A convenient enantioselective decarboxylative aldol reaction to access chiral α-hydroxy esters using β-keto acids
We show a convenient decarboxylative aldol process using a scandium catalyst and a PYBOX ligand to generate a series of highly functionalized chiral α-hydroxy esters. The protocol tolerates a broad range of β-keto acids with inactivated aromatic and aliphatic α-keto esters. The possible mechanism is rationalized.
متن کاملPoly(α-hydroxy Acids)-Based Cell Microcarriers
Biodegradable poly(α-hydroxyacids) have gained increasing interest in the biomedical field for their use as cell microcarriers thanks to their biodegradability, biocompatibility, tunable mechanical properties/degradation rates and processability. The synthesis of these poly(α-hydroxyacids) can be finely controlled to yield (co)polymers of desired mechanical properties and degradation rates. On ...
متن کاملAntiproliferative Activity of β-Hydroxy-β-Arylalkanoic Acids
Article describes the synthesis of fifteen β-hydroxy-β-arylalkanoic acids by Reformatsky reaction using the 1-ethoxyethyl-2-bromoalkanoates, aromatic or cycloalkyl ketones or aromatic aldehydes. The short survey of previously reported synthetic procedures for title compounds, is given. The majority of obtained compounds exert antiproliferative activity in vitro toward human: HeLa, Fem-X cells, ...
متن کاملChemInform Abstract: Direct Synthesis of β- Hydroxy-α-amino Acids via Diastereoselective Decarboxylative Aldol..
A straightforward metal-free synthesis of anti-β-hydroxy-r-amino acids is described. The organic base-mediated decarboxylative aldol reaction of cheap, readily available r-amidohemimalonates with various aldehydes afforded under very mild conditions anti-β-hydroxy-r-amido esters in high yields and complete diastereoselectivity. Simple one-pot subsequent transformations enabled the corresponding...
متن کاملNew Approaches to Branched β-Amino α-Hydroxy Acids, Taxol Side-chain Analogs
The stereoselective synthesis of β -amino acids and their derivatives has been an active area of research, due to the importance of β -amino acids in various fields [1]. In particular, non-proteinogenic β -amino α-hydroxy acids are found in many natural products and drugs, for example N-benzoyl-3-phenylisoserine as a side-chain of taxol which has been approved for treatment of ovarian and breas...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1946
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)43082-7